Small molecule inhibitors of plasma kallikrein

…, WD Shrader, J Burgess-Henry, H Hu, KC Elrod…

文献索引：Young, Wendy B.; Rai, Roopa; Shrader, William D.; Burgess-Henry, Jana; Hu, Huiyong; Elrod, Kyle C.; Sprengeler, Paul A.; Katz, Bradley A.; Sukbuntherng, Juthamas; Mordenti, Joyce Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 7 p. 2034 - 2036

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被引用次数: 6

摘要

Plasma kallikrein is a serine protease that is involved in pathways of inflammation, complement fixation, coagulation, and fibrinolysis. Herein, we describe the SAR and structural binding modes of a series of inhibitors of plasma kallikrein as well as the pharmacokinetics of a lead analog 11 in rat.