A new synthesis of Rhein

PT Gallagher, TA Hicks, AP Lightfoot, WM Owton

文献索引：Gallagher, Peter T.; Hicks, Terry A.; Lightfoot, Andrew P.; Martin Owton Tetrahedron Letters, 1994 , vol. 35, # 2 p. 289 - 292

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被引用次数: 16

摘要

Abstract A novel synthesis of Rhein (2), the active metabolite of the anti-osteoarthritic drug Diacetyl Rhein (1) has been acehived. Key steps include stereospecific olefination of aldehyde 21 with novel phosphonate 28 and the cyclisation of acid 31 to produce anthracene 32.