Design, synthesis and evaluation of clinafloxacin triazole hybrids as a new type of antibacterial and antifungal agents

Y Wang, GLV Damu, JS Lv, RX Geng, DC Yang…

文献索引：Wang, Yan; Damu, Guri L.V.; Lv, Jing-Song; Geng, Rong-Xia; Yang, Da-Cheng; Zhou, Cheng-He Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 17 p. 5363 - 5366

全文：HTML全文

被引用次数: 42

摘要

A series of clinafloxacin triazole hybrids as a new type of antibacterial and antifungal agents were synthesized for the first time and screened for their antimicrobial efficacy against four Gram-positive bacteria, four Gram-negative bacteria and two fungi by two fold serial dilution technique. The bioactive assay indicated that most of the target compounds displayed broad antimicrobial spectrum and good antibacterial and antifungal activities with low MIC ...