Regiochemistry of N??substitution of some 4 (5)??substituted imidazoles under solvent??free conditions

…, M Haukka, P Vainiotalo, P Aulaskari

文献索引：Oresmaa, Larisa; Taberman, Helena; Haukka, Matti; Vainiotalo, Pirjo; Aulaskari, Paula Journal of Heterocyclic Chemistry, 2007 , vol. 44, # 6 p. 1445 - 1451

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被引用次数: 6

摘要

Imidazole nitrogen can be substituted by applying an alkyl halide as electrophile under basic conditions. Alkylations have also been carried out in neutral conditions, but since the imidazolate anion is a far more effective nucleophile, most alkylations are done in basic conditions. For 2-substituted and symmetrically substituted compounds the reaction is straightforward, although quaternization may occasionally be a problem. Typically N- ...