Regioselective N-alkylation of imidazoles with alcohols over zeolites

Y Ono, Y Izawa, Z Fu

文献索引：Ono, Yoshio; Izawa, Yuriko; Fu, Zi-hua Journal of the Chemical Society, Chemical Communications, 1995 , # 1 p. 9 - 10

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被引用次数: 8

摘要

Vapour-phase alkylation of 4(5)-methylimidazole with MeOH over Y-zeolites selectively gave 1,5-dimethylimidazole in high yield, while the alkylation over Beta-zeolite gave 1,4-dimethylimidazole predominantly. ... Methyl halides or dimethyl sulfate have been used as methyl- ating agents for imidazoles.1-5 However, alkyl halides and dialkyl sulfates are highly toxic and corrosive, and more than a stoichiometric amount of strong bases such as NaNH2 and NaOH is ...