Demethylation of 2, 4-dimethoxyquinolines: the synthesis of atanine

K Jones, X Roset, S Rossiter, P Whitfield

文献索引：Jones, Keith; Roset, Xavier; Rossiter, Sharon; Whitfield, Philip Organic and biomolecular chemistry, 2003 , vol. 1, # 24 p. 4380 - 4383

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被引用次数: 31

摘要

The synthesis of the quinoline alkaloid atanine 6, by selective demethylation of the 2,4-dimethoxyquinoline 11 is presented. An alternative demethylation utilising a thiolate anion leads to the regioisomeric 4-hydroxyquinoline 13. ... The Rutaceae family of plants is the source of over 500 alkaloids containing the quinoline ring system. 1,2 The pharmacological properties of this class of compound have received only limited investigation. Nevertheless, a wide range of medicinal properties ...