Antileukotrienic phenethylamido derivatives of arylalkanoic acids in the treatment of ulcerative colitis

R Junek, M Kverka, A Jandera, V Panajotová…

文献索引：Junek, Richard; Kverka, Miloslav; Jandera, Antonin; Panajotova, Vladimira; Satinsky, Dalibor; Machacek, Milos; Kuchar, Miroslav European Journal of Medicinal Chemistry, 2009 , vol. 44, # 1 p. 332 - 344

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被引用次数: 9

摘要

A series of arylalkanoic acid derivatives bearing methyl (phenethyl) amino groups were prepared and their inhibition of LTB4 biosynthesis was evaluated. Regression analysis showed the slightly different parabolic dependences of this activity on lipophilicity of α- methyl and α-unsubstituted alkanoic acid derivatives. The relationship derived for α- unsubstituted alkanoic acids was extended by previously prepared group of similar ...