Tetrahedron

Mechanistic studies of DCC/HOBt-mediated reaction of 3-phenylpropionic acid with benzyl alcohol and studies on the reactivities of 'active ester'and the related …

MC Sheikh, S Takagi, T Yoshimura, H Morita

文献索引：Sheikh, Md. Chanmiya; Takagi, Shunsuke; Yoshimura, Toshiaki; Morita, Hiroyuki Tetrahedron, 2010 , vol. 66, # 36 p. 7272 - 7278

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被引用次数: 21

摘要

Despite of the extensive study for peptide synthesis, DCC-mediated esterification is left still unclear. Therefore, DCC-and DCC/HOBt-mediated reactions of 3-phenylpropionic acid (1) with benzyl alcohol were carried out under several mechanistic considerations. Further, in order to determine the reactivities of the so-called 'active esters' compounds changing the substituents bearing carbonyl and related derivatives group for the purpose of the ...

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