Synthesis and in vitro cytotoxic evaluation of 1, 3-bisubstituted and 1, 3, 9-trisubstituted β-carboline derivatives

…, H Chen, X Hou, H Guan, Q Chen, Y Ma, A Xu

文献索引：Cao, Rihui; Peng, Wenlie; Chen, Hongsheng; Hou, Xuerui; Guan, Huaji; Chen, Qi; Ma, Yan; Xu, Anlong European Journal of Medicinal Chemistry, 2005 , vol. 40, # 3 p. 249 - 257

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被引用次数: 65

摘要

A series of novel 1, 3-bisubstituted and 1, 3, 9-trisubstituted β-carboline derivatives was synthesized from the starting material l-tryptophan. Cytotoxic activities of these compounds were investigated in vitro. The results showed that 1, 3, 9-trisubstituted β-carboline derivatives had higher cytotoxic activities in vitro than the corresponding 1, 3-bisubstituted compounds. Among all the synthesized 1, 3, 9-trisubstituted β-carboline derivatives, the ...