Aryl acetylenes as mechanism-based inhibitors of cytochrome P450-dependent monooxygenase enzymes

M Foroozesh, G Primrose, Z Guo, LC Bell…

文献索引：Foroozesh, Maryam; Primrose, Ginny; Guo, Zuyu; Bell, L. Chastine; Alworth, William L.; Guengerich, F. Peter Chemical Research in Toxicology, 1997 , vol. 10, # 1 p. 91 - 102

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被引用次数: 83

摘要

Aryl acetylenes have been investigated as inhibitors of cytochrome P450 (P450)-dependent alkoxyresorufin dealkylation activities in liver microsomes prepared from rats exposed to β- naphthoflavone, isosafrole, or phenobarbital. Many of the acetylenes investigated produce ...

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