Catalytic Amide??Mediated Methyl Transfer from Silanes to Alkenes in Fujiwara–Moritani Oxidative Coupling

W Rauf, JM Brown

文献索引：Rauf, Waqar; Brown, John M. Angewandte Chemie - International Edition, 2008 , vol. 47, # 22 p. 4228 - 4230

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被引用次数: 36

摘要

We report the discovery of a catalytic procedure for the silylmoderated methylation of electrophilic alkenes under oxidative coupling conditions. Intermolecular alkyl transfers in Heck-type reactions have previously proved elusive.[1] Directing groups play an important part in palladiumcatalyzed aromatic CÀH activation processes.[2] Most of these reactions are considered to involve a palladacycle intermediate. The electrophilic nature of the ...