3'-O-Formyl-(N-acyl)-2'-deoxyribonucleosides as building units in the synthesis of oligodeoxyribonucleotides

J Smrt

文献索引：Smrt, Jiri Collection of Czechoslovak Chemical Communications, 1982 , vol. 47, # 8 p. 2157 - 2169

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被引用次数: 8

摘要

Abstract 5'-O-Dimethoxytrityl-(N-acyl)-2'-deoxyribonucleosides afford 3'-O-formyl-(N-acyl)-2'- deoxyribonucleosides Ia-Id by the action of formic acetic anhydride followed by the action of 80% aqueous acetic acid. The formyl group is removed from Ia-Id by treatment with 1 mol l-1 triethylamine 3'-O-Formyl-2'-deoxythymidine (Ia) gives 3'-O-dimethoxytrityl-2'- deoxythymidine (V) by subsequent treatment with acetic anhydride, triethylamine, ...