Thromboxane A2 synthase inhibitors. 5-(3-Pyridylmethyl) benzofuran-2-carboxylic acids

…, JW Aiken, NJ Crittenden, RR Gorman

文献索引：Johnson; Nidy; Aiken; Crittenden; Gorman Journal of medicinal chemistry, 1986 , vol. 29, # 8 p. 1461 - 1468

被引用次数: 37

摘要

The synthesis and screening of a series of 5-(3-pyridylmethyl) benzofuran-2-carboxylc acids as selective thromboxane A2 (TxA,) synthase inhibitors is outlined. The ability of these compounds to inhibit TxA2 biosynthesis was assayed using microsomal enzyme from human platelets. Substitution of the benzofuran ring caused small changes in potency; modification of the carboxylic acid group caused modest reductions in potency, and ...

82261-42-5

4-(吡啶-3-基)苯胺

~96%

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Reduction of CYP450 inhibition in the 4-[(1H-imidazol-4-yl) ...

[Berlin, Michael; Ting, Pauline C.; Vaccaro, Wayne D.; Aslanian, Robert; McCormick, Kevin D.; Lee, Joe F.; Albanese, Margaret M.; Mutahi, Mwangi W.; Piwinski, John J.; Shih, Neng-Yang; Duguma, Luli; Solomon, Daniel M.; Zhou, Wei; Sher, Rosy; Favreau, Leonard; Bryant, Matthew; Korfmacher, Walter A.; Nardo, Cymbelene; West Jr., Robert E.; Anthes, John C.; Williams, Shirley M.; Wu, Ren-Long; Susan She; Rivelli, Maria A.; Corboz, Michel R.; Hey, John A. Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 4 p. 989 - 994]

Electrosynthesis of unsymmetrical polyaryls by a SRN1-type r...

[Boy, P.; Combellas, C.; Suba, C.; Thiebault, A. Journal of Organic Chemistry, 1994 , vol. 59, # 16 p. 4482 - 4489]