Efforts toward elucidating Thalidomide's molecular target: an expedient synthesis of the first Thalidomide biotin analogue

…, ME Polomska, M Karimi, LJ Abraham…

文献索引：Stewart, Scott G.; Braun, Carlos J.; Polomska, Marta E.; Karimi, Mahdad; Abraham, Lawrence J.; Stubbs, Keith A. Organic and Biomolecular Chemistry, 2010 , vol. 8, # 18 p. 4059 - 4062

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被引用次数: 7

摘要

Herein we describe the synthesis of the first Thalidomide–biotin analogue in order to initiate investigations into the unknown molecular mode of action of Thalidomide. In this manner we describe the attachment of biotin tether through the Huisgen 1, 3-dipolar cycloaddition or “click” synthetic methodology.