Synthesis and study of benzothiazole conjugates in the control of cell proliferation by modulating Ras/MEK/ERK-dependent pathway in MCF-7 cells

…, S Pushpavalli, N Patel, M Pal-Bhadra

文献索引：Kamal, Ahmed; Faazil, Shaikh; Ramaiah, M. Janaki; Ashraf, Md.; Balakrishna; Pushpavalli; Patel, Nibedita; Pal-Bhadra, Manika Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 20 p. 5733 - 5739

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被引用次数: 12

摘要

Abstract By applying a methodology, a series of benzothiazole–pyrrole based conjugates (4a–r) were synthesized and evaluated for their antiproliferative activity. Compounds such as 4a, 4c, 4e, 4g–j, 4m, 4n, 4o and 4r exhibited significant cytotoxic effect in the MCF-7 cell line. Cell cycle effects were examined for these conjugates at 2 μM as well as 4 μM concentrations and FACS analysis show an increase of G2/M phase cells with ...