Asymmetric aldol reaction of α-ketoesters with isocyanoacetate and isocyanoacetamide catalyzed by a chiral ferrocenylphosphine-gold (I) complex

…, M Sawamura, H Hamashima, T Emura, T Hayashi

文献索引：Ito, Yoshihiko; Sawamura, Mayasa; Hamashima, Hitoshi; Emura, Takashi; Hayashi, Tamio Tetrahedron Letters, 1989 , vol. 30, # 35 p. 4681 - 4684

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被引用次数: 61

摘要

Abstract Asymmetric aldol reaction of α-ketoesters (RCOCOOMe: R= Me, i-Bu, Ph) with methyl isocyanoacetate or N, N-dimethyl-α-isocyanoacetamide in the presence of 1 mol% of a chiral (aminoalkyl) ferrocenylphosphine-gold (I) catalyst proceeded with high enantioselectivity to give corresponding oxazolines of up to 90% ee, which were converted into optically active β-alkyl-β-hydroxyaspartic acid derivatives.