Synthesis of 5-arylated N-arylthiazole-2-amines as potential skeletal muscle cell differentiation promoters

…, B Waldner, K Hilber, MD Mihovilovic

文献索引：Schnuerch, Michael; Waldner, Birgit; Hilber, Karlheinz; Mihovilovic, Marko D. Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 7 p. 2149 - 2154

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被引用次数: 17

摘要

A series of N-arylthiazole-2-amines was prepared and their biological activity for the promotion of skeletal muscle cell differentiation was investigated, a process of significant importance in muscle regeneration. A versatile new synthetic route towards the target compounds was developed and the substrate scope of this methodology was investigated. Introduction of the 2-aminoaryl substituent was carried out via nucleophilic substitution ...