Discovery and development of potent LFA-1/ICAM-1 antagonist SAR 1118 as an ophthalmic solution for treating dry eye

…, J Burnier, KJ Barr, EJ Hanan, JD Oslob…

文献索引：Zhong, Min; Gadek, Thomas R.; Bui, Minna; Shen, Wang; Burnier, John; Barr, Kenneth J.; Hanan, Emily J.; Oslob, Johan D.; Yu, Chul H.; Zhu, Jiang; Arkin, Michelle R.; Evanchik, Marc J.; Flanagan, W. Mike; Hoch, Ute; Hyde, Jennifer; Prabhu, Saileta; Silverman, Jeffrey A.; Wright, Jasmin ACS Medicinal Chemistry Letters, 2012 , vol. 3, # 3 p. 203 - 206

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被引用次数: 20

摘要

LFA-1/ICAM-1 interaction is essential in support of inflammatory and specific T-cell regulated immune responses by mediating cell adhesion, leukocyte extravasation, migration, antigen presentation, formation of immunological synapse, and augmentation of T-cell receptor ...