Green N-methylation of electron deficient pyrroles with dimethylcarbonate

…, NA Magnus, MA Staszak

文献索引：Laurila, Michael L.; Magnus, Nicholas A.; Staszak, Michael A. Organic Process Research and Development, 2009 , vol. 13, # 6 p. 1199 - 1201

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被引用次数: 12

摘要

The N-methylation of electron-deficient pyrroles was affected using dimethyl carbonate in the presence of DMF and catalytic DABCO. This alkylation methodology has proven useful for the alkylation of a variety of pyrroles in 72− 98% yields and is considered to be green chemistry relative to the more common use of methyl halides or dimethyl sulfate.