Synthesis and antiviral activity of certain thiazole C-nucleosides

PC Srivastava, MV Pickering, LB Allen…

文献索引：Srivastava; Pickering; Allen; Streeter; Campbell; Witkowski; Sidwell; Robins Journal of Medicinal Chemistry, 1977 , vol. 20, # 2 p. 256 - 262

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被引用次数: 184

摘要

A general reaction of glycosyl cyanides with liquid hydrogen sulfide in the presence of 4- dimethylaminopyridine to provide the corresponding glycosylthiocarboxamides is described. These glycosylthiocarboxamides were utilized as the precursors for the synthesis of 2-D- ribofuranosylthiazole-4-carboxamide and 2-fl-~-ribofuranosylthiazole-5-carboxamide (23). The structural modification of 2-~-~-ribofuranosylthiazole-4-carboxamide(12) into 2-(2, 3,- ...