Design, synthesis and structure–activity relationships of 3, 5-diaryl-1H-pyrazoles as inhibitors of arylamine N-acetyltransferase

E Fullam, J Talbot, A Abuhammed, I Westwood…

文献索引：Fullam, Elizabeth; Talbot, James; Abuhammed, Areej; Westwood, Isaac; Davies, Stephen G.; Russell, Angela J.; Sim, Edith Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 9 p. 2759 - 2764

全文：HTML全文

被引用次数: 11

摘要

The synthesis and inhibitory potencies of a novel series of 3, 5-diaryl-1H-pyrazoles as specific inhibitors of prokaryotic arylamine N-acetyltransferase enzymes is described. The series is based on hit compound 1 3, 5-diaryl-1H-pyrazole identified from a high-throughout screen that has been carried out previously and found to inhibit the growth of Mycobacterium tuberculosis.