Synthesis, pharmacological activity and comparative QSAR modeling of 1, 5-N, N′-substituted-2-(substituted naphthalenesulphonyl) glutamamides as possible …

AK Halder, N Adhikary, MK Maity, T Jha

文献索引：Halder, Amit Kumar; Adhikary, Nilanjan; Maity, Milan Kumar; Jha, Tarun European Journal of Medicinal Chemistry, 2010 , vol. 45, # 5 p. 1760 - 1771

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被引用次数: 23

摘要

Based on our earlier QSAR study, a series of 1, 5-N, N′-substituted-2-(substituted naphthalenesulphonyl) glutamamides were synthesized as possible anticancer agents. Anticancer activities of these synthesized compounds were evaluated in vivo on Swiss Albino mice against Ehrlich Ascites Carcinoma (EAC) cells where inhibitions of tumor cell and tumor weight were considered as biological activity parameters. A comparative QSAR ...