Phosphonic acid and phosphinic acid tripeptides as inhibitors of glutathionylspermidine synthetase

C Verbruggen, S De Craecker, P Rajan, XY Jiao…

文献索引：Verbruggen, Christophe; De Craecker, Sofie; Rajan, Padinchare; Jiao, Xian-Yun; Borloo, Marianne; Smith, Keith; Fairlamb, Alan H.; Haemers, Achiel Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 3 p. 253 - 258

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被引用次数: 40

摘要

A series of phosphonic and phosphinic acid derivatives of glutathione were synthesized as potential inhibitors of glutathionylspermidine synthetase, an essential enzyme in the biosynthesis of trypanothione in trypanosomatids. The compounds showed moderate activity.