Syntheses and characterization of the acyl glucuronide and hydroxy metabolites of diclofenac

JR Kenny, JL Maggs, X Meng, D Sinnott…

文献索引：Journal of Medicinal Chemistry, , vol. 47, # 11 p. 2816 - 2825

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被引用次数: 80

摘要

... Journal of Medicinal Chemistry. ... Chemistry. 4'-Hydroxydiclofenac 2. The key intermediate here is 2,6-dichloro-4-methoxyaniline 5 (Scheme 1). This compound has been made from the expensive 3,5-dichlorophenol ...