1??Benzyl??1, 2, 3, 4??Tetrahydro?螃漫?Carboline as Channel Blocker of N??Methyl??d??Aspartate Receptors

M Espinoza??Moraga, J Caballero…

文献索引：Espinoza-Moraga, Marlene; Caballero, Julio; Gaube, Friedemann; Winckler, Thomas; Santos, Leonardo S. Chemical Biology and Drug Design, 2012 , vol. 79, # 4 p. 594 - 599

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被引用次数: 6

摘要

N-methyl-D-aspartate (NMDA) receptors belong to the family of ligand-gated ion channels and are important for synaptic plasticity and memory function. The NMDA receptor consists of a voltage-dependent channel permeable to Ca2+ and Na+. In Alzheimer's disease, neuronal degeneration is thought to cause an excessive release of glutamate to the extracellular space, which may in turn mediate prolonged stimulation of the NMDA ...