Conjugate addition/cyclization sequence enables selective and simultaneous fluorescence detection of cysteine and homocysteine

X Yang, Y Guo, RM Strongin

文献索引：Yang, Xiaofeng; Guo, Yixing; Strongin, Robert M. Angewandte Chemie - International Edition, 2011 , vol. 50, # 45 p. 10690 - 10693

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被引用次数: 274

摘要

Biological thiols are essential for maintaining the appropriate redox status of proteins, cells, and organisms.[1] Cysteine (Cys) is an essential amino acid that is involved in protein synthesis, detoxification, and metabolism. Elevated levels of Cys have been associated with neurotoxicity,[2] and Cys deficiency is involved in slowed growth rate, hair depigmentation, edema, lethargy, liver damage, muscle and fat loss, skin lesions, and weakness.[3] ...