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Modeling Sex Differences in the Renin Angiotensin System and the Efficacy of Antihypertensive Therapies
10.1016/j.compchemeng.2018.02.009 2018-02-13 The renin angiotensin system is a major regulator of blood pressure and a target for many anti-hypertensive therapies; yet the efficacy of these treatments varies between the sexes. We use published data for systemic RAS hormones to build separate models for ... |
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Simulation of a triple effect evaporator of a solution of caustic soda, sodium chloride, and sodium sulfate using Aspen Plus
10.1016/j.compchemeng.2018.02.005 2018-02-13 Worldwide, the Chlor-Alkali process is the most well-known method for the production of chlorine (Cl2) and sodium hydroxide (NaOH). NaOH, also known as caustic soda, is a very important alkali with many applications in the processing and production of paper, ... |
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Model order reduction of nonlinear parabolic PDE systems with moving boundaries using sparse proper orthogonal decomposition: Application to hydraulic fracturing
10.1016/j.compchemeng.2018.02.004 2018-02-09 Developing reduced-order models for nonlinear parabolic partial differential equation (PDE) systems with time-varying spatial domains remains a key challenge as the dominant spatial patterns of the system change with time. To address this issue, there have be... |
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A new framework of global sensitivity analysis for the chemical kinetic model using PSO-BPNN
10.1016/j.compchemeng.2018.02.003 2018-02-08 Global sensitivity analysis is a tool that primarily focuses on identifying the effects of uncertain input variables on the output and has been investigated widely in chemical kinetic studies. Conventional variance-based methods, such as Sobol’ sensitivity es... |
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Expanding Scope and Computational Challenges in Process Scheduling
10.1016/j.compchemeng.2018.01.020 2018-02-06 In this paper, we present a brief overview of enterprise-wide optimization and challenges in multiscale temporal modeling and integration of different models for the levels of planning, scheduling and control. Next, we review Generalized Disjunctive Programmi... |
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How to Tighten a Commonly Used MINLP Superstructure Formulation for Simultaneous Heat Exchanger Network Synthesis
10.1016/j.compchemeng.2018.01.011 2018-02-03 MINLP superstructures for heat exchanger network synthesis allow the simultaneous optimization of utility heat loads, the number of heat exchanger units and their area requirements. The algorithms used to solve these nonlinear non-convex optimization problems... |
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The design of optimal mixtures from atom groups using Generalized Disjunctive Programming
10.1016/j.compchemeng.2018.01.016 2018-02-03 A comprehensive computer-aided mixture/blend design methodology for formulating a general mixture design problem where the number, identity and composition of mixture constituents are optimized simultaneously is presented in this work. Within this approach, G... |
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A Scheduling Perspective on the Monetary Value of Improving Process Control
10.1016/j.compchemeng.2018.01.019 2018-02-01 The goal of quantifying the monetary value of process control has been a target of much research since the inception of the field, and methods have been developed for quantifying the value of control in the case of predominantly steady-state processes. Howeve... |
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Experimental and numerical assessment of the hydraulic behavior of a pilot-scale periodic anaerobic baffled reactor (PABR)
10.1016/j.compchemeng.2018.01.014 2018-01-31 A major factor that determines the mixing pattern inside a reactor is the Residence Time Distribution (RTD). The aim of this paper is the study of the hydraulic behavior of a pilot-scale Periodic Anaerobic Baffled Reactor (PABR) through experimental RTD tests... |
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Searching historical data segments for process identification in feedback control loops ☆
10.1016/j.compchemeng.2018.01.018 2018-01-31 Mathematical models of dynamic processes are often required for assessment, diagnosis and improvement of control loop performances in process industries. Data samples collected in daily operations of feedback control loops may enclose data segments suitable f... |