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3123-89-5

3123-89-5结构式

常用中文名：Acetamide,N-[(7S)-10-amino-5,6,7,9-tetrahydro-1,2,3-trimethoxy-9-oxobenzo[a]heptalen-7-yl]-
常用英文名：Acetamide,N-[(7S)-10-amino-5,6,7,9-tetrahydro-1,2,3-trimethoxy-9-oxobenzo[a]heptalen-7-yl]-
CAS号：3123-89-5
分子式：C₂₁H₂₄N₂O₅
分子量：384.42600
发布时间：2017-10-12 07:46:53
更新时间：2025-09-06 16:49:34

英文名	N-[(7S)-10-amino-1,2,3-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
英文别名	Colchicine amide Colchicein-amid Colchicamide Colchiceinamide Colchicamide (VAN) (S)--7-Acetylamino-10-amino-1,2,3-trimethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-on N-((S)-10-amino-1,2,3-trimethoxy-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamide 14-Aminocolchicide 10-demethoxy-10-N-aminocolchicine Colchicamid SKF 3192 Colchicenamide Colchicide,14-amino N-((S)-10-Amino-1,2,3-trimethoxy-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamid

密度	1.28g/cm3
沸点	722.2ºC at 760 mmHg
分子式	C₂₁H₂₄N₂O₅
分子量	384.42600
闪点	390.6ºC
精确质量	384.16900
PSA	99.88000
LogP	3.41730
折射率	1.61

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GH0710000

CHEMICAL NAME :: Colchicine, 10-amino-10-demethoxy-

CAS REGISTRY NUMBER :: 3123-89-5

BEILSTEIN REFERENCE NO. :: 2824077

LAST UPDATED :: 199703

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C21-H24-N2-O5

MOLECULAR WEIGHT :: 384.47

WISWESSER LINE NOTATION :: L B677 MV&T&J CO1 DO1 EO1 JMV1 NZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 29600 ug/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea

REFERENCE :: PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year: 20,284,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 33500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 98,236,1954

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 43 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea

REFERENCE :: PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year: 20,284,1957

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 8900 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. (Leipzig, Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see NSAPCC. Volume(issue)/page/year: 85,235,1920

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 160 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. (Leipzig, Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see NSAPCC. Volume(issue)/page/year: 85,235,1920 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 12 mg/kg/24D-I

TOXIC EFFECTS :: Gastrointestinal - alteration in gastric secretion Gastrointestinal - nausea or vomiting Blood - changes in bone marrow (not otherwise specified)

REFERENCE :: CMJODS Chinese Medical Journal (Beijing, English Edition). (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1975- Adopted vol. no. 92 in 1979. Volume(issue)/page/year: 93,188,1980

64-86-8

~60%

3123-89-5

文献：UNIVERSITY OF BRADFORD Patent: WO2008/125800 A2, 2008 ; Location in patent: Page/Page column 16 ;

64-86-8

7664-41-7

3123-89-5

文献：Santavy Chemicke Listy, 1952 , vol. 46, p. 280,284 Chem.Abstr., 1953 , p. 4325 Full Text Show Details Horowitz; Ullyot Journal of the American Chemical Society, 1952 , vol. 74, p. 587,591

上游产品 2
64-86-8 7664-41-7
下游产品 0

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881567-81-3	1094622-48-6

3123-89-5

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

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