HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Human immunodeficiency virus 1

External ID: CHEMBL5238634

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 23.0
First Page: 15608
Last Page: 15626
DOI: 10.1021/acs.jmedchem.2c00576

Target ChEMBL ID: CHEMBL378
ChEMBL Target Name: Human immunodeficiency virus 1
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
1.451	EC50	=	1451	nM
0.384	EC50	=	384	nM
0.11	EC50	=	110	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Human immunodeficiency virus 1

External ID: CHEMBL5238633

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 23.0
First Page: 15608
Last Page: 15626
DOI: 10.1021/acs.jmedchem.2c00576

Target ChEMBL ID: CHEMBL378
ChEMBL Target Name: Human immunodeficiency virus 1
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.00746	EC50	=	7.46	nM
0.00345	EC50	=	3.45	nM
0.00323	EC50	=	3.23	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Human immunodeficiency virus 1

External ID: CHEMBL5238630

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 23.0
First Page: 15608
Last Page: 15626
DOI: 10.1021/acs.jmedchem.2c00576

Target ChEMBL ID: CHEMBL378
ChEMBL Target Name: Human immunodeficiency virus 1
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.00255	EC50	=	2.55	nM
0.00241	EC50	=	2.41	nM
0.00134	EC50	=	1.34	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Human immunodeficiency virus 1

External ID: CHEMBL5238629

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 23.0
First Page: 15608
Last Page: 15626
DOI: 10.1021/acs.jmedchem.2c00576

Target ChEMBL ID: CHEMBL378
ChEMBL Target Name: Human immunodeficiency virus 1
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.0192	EC50	=	19.2	nM
0.0069	EC50	=	6.9	nM
0.00664	EC50	=	6.64	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Human immunodeficiency virus 1

External ID: CHEMBL5238632

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 23.0
First Page: 15608
Last Page: 15626
DOI: 10.1021/acs.jmedchem.2c00576

Target ChEMBL ID: CHEMBL378
ChEMBL Target Name: Human immunodeficiency virus 1
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
47.5	EC50	>	47500	nM
0.214	EC50	=	214	nM
0.0446	EC50	=	44.6	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Human immunodeficiency virus 1

External ID: CHEMBL5238631

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 23.0
First Page: 15608
Last Page: 15626
DOI: 10.1021/acs.jmedchem.2c00576

Target ChEMBL ID: CHEMBL378
ChEMBL Target Name: Human immunodeficiency virus 1
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.0665	EC50	=	66.5	nM
0.0139	EC50	=	13.9	nM
0.00975	EC50	=	9.75	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：MT4

External ID: CHEMBL5238626

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 23.0
First Page: 15608
Last Page: 15626
DOI: 10.1021/acs.jmedchem.2c00576

Target ChEMBL ID: CHEMBL388
ChEMBL Target Name: MT4
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
13.6	CC50	=	13600	nM
222	CC50	>	222000	nM
740	CC50	=	740000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Human immunodeficiency virus 1

External ID: CHEMBL5238625

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 23.0
First Page: 15608
Last Page: 15626
DOI: 10.1021/acs.jmedchem.2c00576

Target ChEMBL ID: CHEMBL378
ChEMBL Target Name: Human immunodeficiency virus 1
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
1.059	EC50	=	1059	nM
27.418	EC50	=	27418	nM
30.347	EC50	>	30347	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5238628

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 23.0
First Page: 15608
Last Page: 15626
DOI: 10.1021/acs.jmedchem.2c00576

Standard Type	Standard Relation	Standard Value
Ratio CC50/EC50	>	60
Ratio CC50/EC50	=	371
Ratio CC50/EC50	=	857

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5238627

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 23.0
First Page: 15608
Last Page: 15626
DOI: 10.1021/acs.jmedchem.2c00576

Standard Type	Standard Relation	Standard Value
Ratio CC50/EC50	>	1397
Ratio CC50/EC50	=	3989
Ratio CC50/EC50	=	20550

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Human immunodeficiency virus 1

External ID: CHEMBL5238624

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 23.0
First Page: 15608
Last Page: 15626
DOI: 10.1021/acs.jmedchem.2c00576

Target ChEMBL ID: CHEMBL378
ChEMBL Target Name: Human immunodeficiency virus 1
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.0325	EC50	=	32.5	nM
0.068	EC50	=	68	nM
0.057	EC50	=	57	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5238641

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 23.0
First Page: 15608
Last Page: 15626
DOI: 10.1021/acs.jmedchem.2c00576

Standard Type	Standard Relation	Standard Value	Standard Units
Solubility	=	5.7	ug.mL-1
Solubility	=	38.9	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Reverse transcriptase/RNaseH

External ID: CHEMBL5238638

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 23.0
First Page: 15608
Last Page: 15626
DOI: 10.1021/acs.jmedchem.2c00576

Target ChEMBL ID: CHEMBL247
ChEMBL Target Name: Human immunodeficiency virus type 1 reverse transcriptase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.03	IC50	=	30	nM
0.04	IC50	=	40	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5238640

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 23.0
First Page: 15608
Last Page: 15626
DOI: 10.1021/acs.jmedchem.2c00576

Standard Type	Standard Relation	Standard Value	Standard Units
Solubility	=	12.3	ug.mL-1
Solubility	=	149	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5238639

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 23.0
First Page: 15608
Last Page: 15626
DOI: 10.1021/acs.jmedchem.2c00576

Standard Type	Standard Relation	Standard Value	Standard Units
Solubility	=	23.1	ug.mL-1
Solubility	=	349	ug.mL-1

2834087-69-1 靶点实验数据