HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1931997

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2011
Volume: 19
Issue: 23
First Page: 7085
Last Page: 7092
DOI: 10.1016/j.bmc.2011.10.001

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
10.6	IC50	=	10600	nM
25.8	IC50	=	25800	nM
5.5	IC50	=	5500	nM
10.8	IC50	=	10800	nM
16.4	IC50	=	16400	nM
22.3	IC50	=	22300	nM
14.3	IC50	=	14300	nM
29.6	IC50	=	29600	nM
68	IC50	=	68000	nM
24	IC50	=	24000	nM
23.5	IC50	=	23500	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1931999

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2011
Volume: 19
Issue: 23
First Page: 7085
Last Page: 7092
DOI: 10.1016/j.bmc.2011.10.001

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.7	IC50	=	700	nM
12	IC50	=	12000	nM
3.7	IC50	=	3700	nM
12.3	IC50	=	12300	nM
16.9	IC50	=	16900	nM
3.5	IC50	=	3500	nM
2.6	IC50	=	2600	nM
1.5	IC50	=	1500	nM
0.4	IC50	=	400	nM
8.1	IC50	=	8100	nM
2.5	IC50	=	2500	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1931998

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2011
Volume: 19
Issue: 23
First Page: 7085
Last Page: 7092
DOI: 10.1016/j.bmc.2011.10.001

Standard Type	Activity Comment
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL2321604

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2013
Volume: 23
Issue: 1
First Page: 183
Last Page: 187
DOI: 10.1016/j.bmcl.2012.10.133

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
GI	=	47.4	%
GI	=	75.9	%
GI	=	17.2	%
GI	=	64.1	%
GI	=	59.9	%
GI	=	30.7	%
GI	=	26.5	%
GI	=	42.3	%
GI	=	32	%
GI	=	30.7	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Aldo-keto reductase family 1 member B1

External ID: CHEMBL981183

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2008
Volume: 16
Issue: 15
First Page: 7470
Last Page: 7476
DOI: 10.1016/j.bmc.2008.06.004

Target ChEMBL ID: CHEMBL2622
ChEMBL Target Name: Aldose reductase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
0.07762	IC50	=	77.62	nM
0.0389	IC50	=	38.9	nM
1.41254	IC50	=	1412.54	nM
0.23988	IC50	=	239.88	nM
1000	IC50	=	1000000	nM	Outside typical range
18.6209	IC50	=	18620.87	nM
0.03236	IC50	=	32.36	nM
6.76083	IC50	=	6760.83	nM
0.02799	IC50	=	27.99	nM
0.34834	IC50	=	348.34	nM
0.20417	IC50	=	204.17	nM
0.81283	IC50	=	812.83	nM
5.24807	IC50	=	5248.07	nM
0.25119	IC50	=	251.19	nM
0.26915	IC50	=	269.15	nM
0.28184	IC50	=	281.84	nM
0.302	IC50	=	302	nM
0.40738	IC50	=	407.38	nM
0.85114	IC50	=	851.14	nM
1.20226	IC50	=	1202.26	nM

36950-98-8 靶点实验数据