HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HEK-293T

External ID: CHEMBL5635118

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2023
Volume: 260
First Page: 115731
Last Page: 115731
DOI: 10.1016/j.ejmech.2023.115731

Target ChEMBL ID: CHEMBL3706568
ChEMBL Target Name: HEK-293T
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
198.99	CC50	=	198990	nM
30.66	CC50	=	30660	nM
99.85	CC50	=	99850	nM
52.77	CC50	=	52770	nM
171.84	CC50	=	171840	nM
117.61	CC50	=	117610	nM
59.87	CC50	=	59870	nM
34.38	CC50	=	34380	nM
181.02	CC50	=	181020	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5635119

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2023
Volume: 260
First Page: 115731
Last Page: 115731
DOI: 10.1016/j.ejmech.2023.115731

Standard Type	Standard Relation	Standard Value
Ratio IC50	>	1.91
Ratio IC50	>	16.41
Ratio IC50	=	5.65
Ratio IC50	=	1.04
Ratio IC50	=	5.72
Ratio IC50	=	2.7
Ratio IC50	=	5.85
Ratio IC50	=	4.79
Ratio IC50	=	1.77

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：RAW264.7

External ID: CHEMBL5635120

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2023
Volume: 260
First Page: 115731
Last Page: 115731
DOI: 10.1016/j.ejmech.2023.115731

Target ChEMBL ID: CHEMBL612557
ChEMBL Target Name: RAW264.7
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	~	30	%
Inhibition	~	30	%
Inhibition	~	30	%
Inhibition	~	30	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：RAW264.7

External ID: CHEMBL5635113

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur J Med Chem
Year: 2023
Volume: 260
First Page: 115731
Last Page: 115731
DOI: 10.1016/j.ejmech.2023.115731

Target ChEMBL ID: CHEMBL612557
ChEMBL Target Name: RAW264.7
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
3.72	IC50	=	3720	nM
189.76	IC50	=	189760	nM	Outside typical range
3.77	IC50	=	3770	nM
4.12	IC50	=	4120	nM
5.07	IC50	=	5070	nM
106.44	IC50	=	106440	nM	Outside typical range
200	IC50	>	200000	nM	Outside typical range
3.86	IC50	=	3860	nM
3.7	IC50	=	3700	nM
160.75	IC50	=	160750	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：RAW264.7

External ID: CHEMBL5635114

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur J Med Chem
Year: 2023
Volume: 260
First Page: 115731
Last Page: 115731
DOI: 10.1016/j.ejmech.2023.115731

Target ChEMBL ID: CHEMBL612557
ChEMBL Target Name: RAW264.7
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
5.69	CC50	=	5690	nM
199.62	CC50	=	199620	nM
5.46	CC50	=	5460	nM
12.78	CC50	=	12780	nM
18.91	CC50	=	18910	nM
138.36	CC50	=	138360	nM
200	CC50	>	200000	nM
20.37	CC50	=	20370	nM
5.06	CC50	=	5060	nM
191.31	CC50	=	191310	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5635117

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur J Med Chem
Year: 2023
Volume: 260
First Page: 115731
Last Page: 115731
DOI: 10.1016/j.ejmech.2023.115731

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
137.14	IC50	=	137140	nM	Outside typical range
9.92	IC50	=	9920	nM
96.07	IC50	=	96070	nM
12.14	IC50	=	12140	nM
41.2	IC50	=	41200	nM
24.55	IC50	=	24550	nM
33.73	IC50	=	33730	nM
6.3	IC50	=	6300	nM
156.84	IC50	=	156840	nM	Outside typical range

573-57-9 靶点实验数据