2-Polystyrylsulfonyl ethanol supports for the solid-phase syntheses of hydantoins and ureas

W Huang, S Cheng, W Sun

Index: Huang, Wenqiang; Cheng, Shaoling; Sun, Weimin Tetrahedron Letters, 2001 , vol. 42, # 10 p. 1973 - 1974

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Citation Number: 25

Abstract

Reaction of sodium polystyrylsulfinate 1 with 2-chloroethanol gave the 2-arylsulfonyl ethanol resin 2, which was converted to the polymer-supported amine 5. Amine 5 was coupled with an isocyanate or an isothiocyanate to give the polymer-supported urea derivatives 6. Treatment of the resin 6 with 6N HCl gave hydantoins 7, while reaction of the same resin with 4N NaOH then HCl gave the urea derivatives 8.