… of Terminal Alkynes for the Synthesis of Alk??2??ynamides by Using Palladium??on??Carbon as Efficient, Heterogeneous, Phosphine??Free, and Reusable Catalyst

…, MV Khedkar, SR Lanke, BM Bhanage

Index: Gadge, Sandip T.; Khedkar, Mayur V.; Lanke, Satish R.; Bhanage, Bhalchandra M. Advanced Synthesis and Catalysis, 2012 , vol. 354, # 10 p. 2049 - 2056

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Citation Number: 39

Abstract

Abstract Palladium-on-carbon (Pd/C)-catalyzed oxidative aminocarbonylations of alk-1-ynes with secondary amines provide the corresponding alk-2-ynamides in a good to excellent yields. This new methodology is applicable for the synthesis of a wide range of biologically active alk-2-ynamide derivatives. The developed protocol avoids the use of phosphine ligands, with an additional advantage of palladium catalyst recovery and reuse for up to ...