Preparation of polystyrene-supported vinyl sulfone and its application in the solid-phase organic synthesis of 1-monosubstituted 1, 2, 3-triazoles

Z Huang, R Wang, S Sheng, R Zhou, M Cai

Index: Huang, Zhenzhong; Wang, Ruiling; Sheng, Shouri; Zhou, Ruyi; Cai, Mingzhong Reactive and Functional Polymers, 2013 , vol. 73, # 1 p. 224 - 227

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Citation Number: 9

Abstract

A polystyrene-supported vinyl sulfone reagent was prepared and used for the solid-phase organic synthesis of 1-monosubstituted 1, 2, 3-triazoles via a 1, 3-dipolar cycloaddition reaction with azides and subsequent cleavage from the polymer support through an elimination reaction in the presence of potassium tert-butoxide. The advantages of this method include straightforward operation, good yield and high purity of the crude products.

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