New polyfunctional imidazo [4, 5-C] pyridine motifs: Synthesis, crystal studies, docking studies and antimicrobial evaluation

…, JP Jasinski, SP Millikan, N Chandrika, SS More…

Index: Jose, Gilish; Suresha Kumara; Nagendrappa, Gopalpur; Sowmya; Jasinski, Jerry P.; Millikan, Sean P.; Chandrika; More, Sunil S.; Harish European Journal of Medicinal Chemistry, 2014 , vol. 77, p. 288 - 297

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Citation Number: 10

Abstract

Abstract New antimicrobial agents, imidazo [4, 5-c] pyridine derivatives have been synthesized. We have developed a new synthetic protocol for the final reaction, an efficient microwave-assisted synthesis of imidazo [4, 5-c] pyridines from substituted 3, 4- diaminopyridine and carboxylic acids in presence of DBU mediated by T3P. The chemical structures of the new compounds were characterized by IR, 1 H NMR, 13 C NMR, mass ...