Helvetica chimica acta

Distamycin??NA: A DNA Analog with an Aromatic Heterocyclic Polyamide Backbone. Part 1. Synthesis and structural analysis of monomers and dimers containing the …

G Sauter, E Stulz, C Leumann

Index: Sauter, Guido; Stulz, Eugen; Leumann, Christian Helvetica Chimica Acta, 1998 , vol. 81, # 1 p. 14 - 34

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Citation Number: 7

Abstract

Abstract The synthesis of the monomeric building block 13 and its constitutional isomer 12 of a new type of DNA analog, distamycin-NA, is presented (Schemes 1 and 2). This building block consists of a uracil base attached to a thiophene core unit via a biaryl-like axis. Next to the biaryl-like axis on the thiophene chromophore, a carboxy and an amino substituent are located allowing for oligomerization via peptide coupling. The proof of constitution and the ...

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Potent selective thienoxazinone inhibitors of herpes proteas...

[Jarvest, Richard L.; Connor, Susan C.; Gorniak, Joselina G.; Jennings, L. John; Serafinowska, Halina T.; West, Andrew Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 13 p. 1733 - 1738]

p38 kinase inhibitors for the treatment of arthritis and ost...

[Redman, Aniko M; Johnson, Jeffrey S.; Dally, Robert; Swartz, Steve; Wild, Hanno; Paulsen, Holger; Caringal, Yolanda; Gunn, David; Renick, Joel; Osterhout, Martin; Kingery-Wood, Jill; Smith, Roger A.; Lee, Wendy; Dumas, Jacques; Wilhelm, Scott M.; Housley, Timothy J.; Bhargava, Ajay; Ranges, Gerald E.; Shrikhande, Alka; Young, Deborah; Bombara, Michael; Scott, William J. Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 1 p. 9 - 12]