A great improvement of the enantioselectivity of lipase-catalyzed hydrolysis and esterification using co-solvents as an additive

T Nishigaki, Y Yasufuku, S Murakami, Y Ebara…

Index: Nishigaki, Tomohiro; Yasufuku, Yoshitaka; Murakami, Sayuri; Ebara, Yasuhito; Ueji, Shin-Ichi Bulletin of the Chemical Society of Japan, 2008 , vol. 81, # 5 p. 617 - 622

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Citation Number: 6

Abstract

Addition of co-solvents such as tetrahydrofuran resulted in a great improvement of the enantioselectivity of lipase-catalyzed hydrolysis of butyl 2-(4-substituted phenoxy) propanoates in an aqueous buffer solution. On the other hand, lipase lyophilized from an aqueous solution containing the co-solvents catalyzed highly enantioselective esterification of 2-(4-substituted phenoxy) propionic acids, 2-(4-isobutylphenyl) propionic acid ( ...