Synlett

Facile Catalytic SNAr Reaction of Nonactivated Fluoroarenes with Amines Using η6-Benzene Ruthenium (II) Complex

M Otsuka, H Yokoyama, K Endo, T Shibata

Index: Otsuka, Maiko; Yokoyama, Hiroya; Endo, Kohei; Shibata, Takanori Synlett, 2010 , # 17 p. 2601 - 2606

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Citation Number: 4

Abstract

Abstract Catalytic SN Ar reaction of fluoroarenes possessing no electron-withdrawing group (s) with cyclic amines was achieved using a readily accessible Ru catalyst, which was prepared from [Ru (benzene) Cl 2] 2, AgOTf, and P (p-FC 6 H 4) 3. The coexistence of molecular sieves MS4A realized high conversion and various substituted aryl amines were obtained in good to high yields.

~53%

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~85%

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