Simple, efficient protocols for the Pd-catalyzed cross-coupling reaction of aryl chlorides and dimethylamine

BK Lee, MR Biscoe, SL Buchwald

Index: Lee, Brian K.; Biscoe, Mark R.; Buchwald, Stephen L. Tetrahedron Letters, 2009 , vol. 50, # 26 p. 3672 - 3674

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Citation Number: 29

Abstract

Simple and efficient procedures for the Pd-catalyzed cross-coupling reaction of aryl chlorides and dimethylamine are described. At room temperature with a strong base, t- BuXPhos is employed as the supporting ligand; at 110° C with a weak base, XPhos is employed as the supporting ligand. In each of these cases, commercially available solutions constitute the source of the dimethylamine, and recently disclosed precatalysts constitute ...