Sex pheromone biosynthesis in the female olive fruit-fly. Double labelling from [18O2]-dioxygen into 1,7-dioxaspiro[5.5]undecane.

Mary T Fletcher, Basilis E Mazomenos, John H Georgakopoulos, Maria A Konstantopoulou, Barry J Wood, James J De Voss, William Kitching

Index: Chem. Commun. (Camb.) (12) , 1302-3, (2002)

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Abstract

The demonstration that both oxygen atoms of 1,7-dioxaspiro[5.5]undecane (1), the sex-pheromone of the female olive fly, originate from dioxygen, strongly implicates monooxygenase mediated processes in assembly of (1), and reveals unexpected complexity in the formation of its nine-carbon precursor.