Carcinogenicity test of acetoxime in MRC-Wistar rats.

S S Mirvish, S Salmasi, R G Runge

Index: J. Natl. Cancer Inst. 69(4) , 961-2, (1982)

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Abstract

Acetoxime was tested for carcinogenicity by chronic administration in the drinking water to male and female outbred MRC-Wistar rats. The dose of 1.0 g/liter was administered 5 days/week for 18 months (total dose, 6.2--7.0 g/rat). The test compound induced benign hepatocellular adenomas in 80% of the males but did not produce tumors in the females. This is the first report that oximes, which are fairly widely used in industry, are tumorigenic.