An Efficient one-pot Biginelli condensation of aliphatic aldehydes catalyzed by zinc bromide under solvent-free conditions.

Yang Yu, Di Liu, Chunsheng Liu, Heng Jiang, Genxiang Luo

Index: Prep Biochem Biotechnol. 37(4) , 381-7, (2007)

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Abstract

Zinc bromide catalyzes the three component condensation reaction of an aldehyde, urea, and beta-ketoester or beta-diketone under solvent-free conditions to afford the corresponding dihydropyrimidinones (DHPMs) with moderate to high yields in short reaction time. The present method is very effective for the Biginelli condensation of aliphatic aldehydes.