Silyl protecting groups for oligonucleotide synthesis removed by a ZnBr2 treatment.

Fernando Ferreira, François Morvan

Index: Nucleosides Nucleotides Nucleic Acids 24(5-7) , 1009-13, (2005)

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Abstract

An oligonucleotide protected with N-(trimethylsilyloxycarbonyl) (Teoc) and P-(trimethylsilylethanol) (Tse) groups was synthesized and deprotected by a single ZnBr2 treatment. Finally it was released from the solid support by cleavage of a disulfide linkage with TCEP. The olgonucleotide was obtained without any basic treatment.