A-72363 A-1, A-2 and C, novel heparanase inhibitors from Streptomyces nobilis SANK 60192. I. Taxonomy of producing organism, fermentation, isolation and structure elucidation.

T Takatsu, M Takahashi, Y Kawase, R Enokita, T Okazaki, H Matsukawa, K Ogawa, Y Sakaida, T Kagasaki, T Kinoshita, M Nakajima, K Tanzawa

Index: J. Antibiot. 49(1) , 54-60, (1996)

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Abstract

Novel heparanse inhibitors, A72363 A-1, A-2, and C, were isolated from the culture filtrate of Streptomyces nobilis SANK 60192 by column chromatography on various resinous adsorbents, followed by preparative anion exchange HPLC. Spectroscopic studies revealed that they are diastereomers of siastatin B, a neuraminidase inhibitor.