Levels of acetyl hydrazines and rate of acetylation of isoniazid in adult tuberculosis patients.

E B Bhalerao, S V Bhide

Index: Indian J. Physiol. Pharmacol. 29(2) , 83-8, (1985)

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Abstract

Patients suffering from pulmonary tuberculosis were investigated for the levels of isoniazid (INH) and its metabolites viz. acetyl-INH, mono and diacetyl hydrazines and ammonia. It was observed that 50% of the patients are slow inactivators of INH and almost all show an increase in circulating levels of NH3 at 6 hrs. Mono and diacetyl hydrazine levels in blood and urine were detectable in all the patients up+o 24 hrs though the maximum levels were observed at different intervals after the intake of INH.