Synthesis of 1-alkyl-1, 2, 4-triazoles: a new one-pot regiospecific procedure

BA Astleford, GL Goe, JG Keay…

Index: Astleford, Bret A.; Goe, Gerald L.; Keay, James G.; Scriven, Eric F. V. Journal of Organic Chemistry, 1989 , vol. 54, # 3 p. 731 - 732

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Citation Number: 46

Abstract

Regiospecific alkylation of 1, 2, 4-triazoles provides a synthetic challenge. 2 Direct alkylation of 1, 2, 4-triazole affords usually a mixture of mainly 1-and some 4-substituted pr~ duct.~ Ratios vary with the nature of the alkylating agent and conditions but frequently range from 70: 30 to 9010. Preparation of 1-substituted 1, 2, 4-triazoles has become important of late, as a number of such triazoles has been found to be very effective agricultural fungicides? ...

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Synthesis and structure–activity relationship of 1-and 2-sub...

[Doiron, Jeremie; Soultan, Al Haliffa; Richard, Ryan; Toure, Mamadou Mansour; Picot, Nadia; Richard, Remi; Cuperlovic-Culf, Miroslava; Robichaud, Gilles A.; Touaibia, Mohamed European Journal of Medicinal Chemistry, 2011 , vol. 46, # 9 p. 4010 - 4024]

… -activity relationships of 1, 4-dihydro-(1H, 4H)-quinoxali...

[Abenhaim, David; Diez-Barra, Enrique; Hoz, Antonio de la; Loupy, Andre; Sanchez-Migallon, Ana Heterocycles, 1994 , vol. 38, # 4 p. 793 - 802]

An investigation into the alkylation of 1, 2, 4-triazole

[Bulger, Paul G.; Cottrell, Ian F.; Cowden, Cameron J.; Davies, Antony J.; Dolling, Ulf-H. Tetrahedron Letters, 2000 , vol. 41, # 8 p. 1297 - 1301]

Etude dans la serie des organosilylazoles: I. Action des hal...

[Gasparini, J. P.; Gassend, R.; Maire, J. C.; Elguero, J. Journal of Organometallic Chemistry, 1980 , vol. 188, # 2 p. 141 - 150]

N-Alkylation of amines with alcohols over nanosized zeolite ...

[Reddy, Marri Mahender; Kumar, Macharla Arun; Swamy, Peraka; Naresh, Mameda; Srujana, Kodumuri; Satyanarayana, Lanka; Venugopal, Akula; Narender, Nama Green Chemistry, 2013 , vol. 15, # 12 p. 3474 - 3483]