Caesium fluoride-promoted Stille coupling reaction: an efficient synthesis of 9Z-retinoic acid and its analogues using a practical building block.

Takashi Okitsu, Kinya Iwatsuka, Akimori Wada

Index: Chem. Commun. (Camb.) (47) , 6330-2, (2008)

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Abstract

A highly efficient and rapid total synthesis of 9Z-retinoic acid was accomplished by caesium fluoride-promoted Stille coupling reaction; using a common building block, 9Z-retinoic acid analogues were also prepared by the same method without isomerisation of the Z-double bond.