Anticonvulsant properties of N-salicyloyltryptamine in mice.

F A Oliveira, R N de Almeida, M F Sousa, J M Barbosa-Filho, S A Diniz, I A de Medeiros

Index: Pharmacol. Biochem. Behav. 68 , 199-202 , (2001)

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Abstract

A new tryptamine analogue, N-salicyloyltryptamine (STP), a potential central nervous system (CNS) depressant, was tested in the pentylenetetrazol (PTZ) and maximal electroshock (MES) models of epilepsy in mice. When administered concurrently, STP (100 mg/kg ip) significantly reduced the number of animals that exhibited PTZ-induced seizures and eliminated the extensor reflex of maximal electric-induced seizures test in 50% of the experimental animals. In addition, it showed protection in the PTZ test by diminishing the death rate.