Synthesis of bis-ureas from bis(o-nitrophenyl) carbonate.

Maria-Cristina Turoczi, Monika Simon, Valentin Badea, Carol Csunderlik

Index: Molecules 13(12) , 3192-7, (2008)

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Abstract

A general method for the preparation of bis-ureas from bis(o-nitrophenyl) carbonate has been developed. Directional urea synthesis is achieved by sequential amine addition to bis(o-nitrophenyl) carbonate in two steps: in the first step bis(o-nitrophenyl) carbonate is reacted with benzylamine to form benzyl-o-nitrophenyl carbamate; in the second step the carbamate is reacted with a variety of diamines in toluene to yield bis-ureas.