Piericidins C5 and C6: new 4-pyridinol compounds produced by Streptomyces sp. and Nocardioides sp.

Natsuki K Kubota, Emi Ohta, Shinji Ohta, Fumito Koizumi, Makoto Suzuki, Michio Ichimura, Susumu Ikegami

Index: Bioorg. Med. Chem. 11(21) , 4569-75, (2003)

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Abstract

Piericidins C5 (1) and C6 (2), two new members of the piericidin family, were isolated from a Streptomyces sp. and a Nocardioides sp., together with known piericidins C1 (3), C2 (4), C3 (5), C4 (6), D1 (7), and A3 (8). The structures were determined on the basis of their spectroscopic data. Both new compounds inhibited cell division of fertilized starfish (Asterina pectinifera) eggs at the minimum inhibitory concentration of 0.09 microg/mL.